Reaktion #82762

ord-ab8fe664e4a243db903ea0c0168088b4

Reaktionsgleichung

O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O
7-chloro-1-cyclopropyl-6-fluoro -1, 4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
c1cncc(C2CCNC2)c1
3-(3-pyrrolidinyl) pyridine
O=C(O)c1cn(C2CC2)c2nc(N3CCC(c4cccnc4)C3)c(F)cc2c1=O
title compound
Ausbeute 82.0%
O=C(O)c1cn(C2CC2)c2nc(N3CCC(c4cccnc4)C3)c(F)cc2c1=O
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-1,8-naphthyridine-3-carboxylic acid
Ausbeute 82.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Starting from 7-chloro-1-cyclopropyl-6-fluoro -1, 4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1.24 g, 4.4 mmol) and 3-(3-pyrrolidinyl) pyridine, a procedure analogous to that given in Example 1 provided the title compound (1.43 g, 82%) as a light beige solid, mp 226°-228° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05622966uspto-grants-1997_04