Reaktion #8276

Reaktionsgleichung

water

carbon dioxide

Di-(t-butoxycarbonyl)aminopyrazine

sodium hydroxide

→

title product

Ausbeute 74.2%

t-Butoxycarbonylaminopyrazine

Ausbeute 74.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigemethanol evaporated
2. 2
   ExtraktionThe residual aqueous solution was extracted with dichloromethane (2×20 ml)
3. 3
   Waschenthe extracts washed with brine (20 ml)
4. 4
   Sonstigeevaporated
5. 5
   SonstigeThe resulting solid was triturated with isohexane (50 ml)

Vorschrift

Di-(t-butoxycarbonyl)aminopyrazine (2.1 g, 7.1 mM) in methanol (50 ml) under nitrogen, was treated with aqueous sodium hydroxide (2.5 M, 2.84 ml, 7.1 mM), and stirred at ambient temperature for 2 hours. The mixture was neutralised by the addition of water (25 ml) and solid carbon dioxide, then methanol evaporated. The residual aqueous solution was extracted with dichloromethane (2×20 ml), the extracts washed with brine (20 ml) and evaporated. The resulting solid was triturated with isohexane (50 ml) to give the title product as a white solid (1.03 g).

Quelle