Reaktion #82742

Reaktionsgleichung

cyanogen bromide

4-isopropylaniline

→

4-isopropylphenyl cyanamide

Ausbeute 84.0%

Lösungsmittel

diethylether

diethylether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe reaction mixture was kept stirring at room temperature for 18 h
3. 3
   SonstigeThen a solution with white precipitates
4. 4
   Sonstigeformed
5. 5
   Sonstigethe precipitates were removed by filtration
6. 6
   WaschenThe etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
7. 7
   Trocknendried over MgSO4
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated
10. 10
    Sonstigedried under vacuum

Vorschrift

A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).

Quelle