Reaktion #82694

Reaktionsgleichung

5-chloromethyl-3-methoxy-isoxazole

triethylphosphite

chloromethyl isoxazole

→

diethyl (3-methoxy-isoxazol-5-yl)-methane phosphonate

Ausbeute 56.1%

Reaktionsbedingungen

Vorschrift

3.8 g 5-chloromethyl-3-methoxy-isoxazole and 6.0 g of triethylphosphite were stirred at 150° C. until complete conversion of the chloromethyl isoxazole (2-8 h). Kugelrohr destillation gave 3.6 g of diethyl (3-methoxy-isoxazol-5-yl)-methane phosphonate. Bp. 160°-165° C./0.3 mm Hg.

Quelle