Reaktion #82628

ord-f8d45949bb8a4b66846a75e9e847fc32

Reaktionsgleichung

O=c1[nH]c2c(Cl)cc(C(F)(F)F)c([N+](=O)[O-])c2[nH]c1=O
5-chloro-8-nitro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione
[Cl][Sn][Cl]
SnCl2
→
Nc1c(C(F)(F)F)cc(Cl)c2[nH]c(=O)c(=O)[nH]c12
title compound
Ausbeute 93.9%
Nc1c(C(F)(F)F)cc(Cl)c2[nH]c(=O)c(=O)[nH]c12
8-Amino-5-chloro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione
Ausbeute 93.9%

Edukte

O=c1[nH]c2c(Cl)cc(C(F)(F)F)c([N+](=O)[O-])c2[nH]c1=O
5-chloro-8-nitro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione
[Cl][Sn][Cl]
SnCl2

Reagenzien

Keine

Lösungsmittel

CCO
EtOH

Reaktionsbedingungen

Temperatur
75°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A mixture of 5-chloro-8-nitro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione (25 mg, 0.08 mmol), SnCl2 ·2 H2O (97 mg, 0.34 mmol) and EtOH (3 mL) was heated at 75° C. with stirring for 12 h. Work-up as above gave 21 mg (93%) of the title compound as a yellow powder. Mp>360° C. 1H NMR (DMSO-d6) 11.441 (s, 1H), 11.324 (s, 1H), 7.241 (s, 1H), 5.916 (s, 2H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05622952uspto-grants-1997_04