Reaktion #8249

Reaktionsgleichung

sodium bicarbonate

Pyridine

5-Amino-2-(2-methylimidazol-1-yl)fluorobenzene

benzyl chloroformate

→

title product

Ausbeute 93.5%

5-Benzyloxycarbonylamino-2-(2-methylimidazol-1-yl)fluorobenzene

Ausbeute 93.5%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to −5°
2. 2
   Sonstigethe organic layer separated
3. 3
   Extraktionthe aqueous layer re-extracted with dichloromethane (2×300 ml)
4. 4
   Trocknendried (magnesium sulfate)
5. 5
   FiltrationAfter filtration and evaporation
6. 6
   Sonstigethe residue was recrystallised from toluene (400 ml)

Vorschrift

5-Amino-2-(2-methylimidazol-1-yl)fluorobenzene (34.25 g, 0.179 M) was dissolved in dry dichloromethane (600 ml) under nitrogen, and cooled to −5°. Pyridine (17.7 g, 0.224 M) was added, followed by benzyl chloroformate (33.7 g, 0.197 M) over 20 minutes. The mixture was stirred and the temperature allowed to rise to ambient over 16 hours. Aqueous sodium bicarbonate (5%, 250 ml) was added, the organic layer separated, the aqueous layer re-extracted with dichloromethane (2×300 ml), and combined extracts dried (magnesium sulfate). After filtration and evaporation, the residue was recrystallised from toluene (400 ml) to give title product (54.5 g).

Quelle