Reaktion #824349

Reaktionsgleichung

4-(2-Bromo-acetyl)-benzonitrile

thiourea

NaOAc

→

desired product

4-(2-Amino-thiazol-4-yl)-benzonitrile

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated under reduced pressure

Vorschrift

4-(2-Bromo-acetyl)-benzonitrile (2.9 g, 12.9 mmol) was combined with 1.0 g (12.9 mmol) of thiourea. This mixture was suspended in 60 mL of EtOH. To this suspension was added NaOAc (1.4 g, 16.8 mmol). This suspension was stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure to yield the desired product.

Quelle