Reaktion #824329

Reaktionsgleichung

2-Phenylmorpholine

4′-Bromoacetophenone

→

4-[1-(4-Bromo-phenyl)-ethyl]-2-phenyl-morpholine

Lösungsmittel

methylene chloride

dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITION1.5 eq. borane-pyridine complex could be added
2. 2
   Waschenwashed with water and brine
3. 3
   TrocknenThe organics could be dried over sodium sulfate
4. 4
   Sonstigepurified by column chromatography

Vorschrift

The above compound could be made the following way: 1 eq. of 2-Phenylmorpholine (Array) in dichloroethane could be combined with 1.2 eq. 4′-Bromoacetophenone (Aldrich) and stirred overnight at room temperature. 1.5 eq. borane-pyridine complex could be added and the reaction stirred for several hours. The reaction mixture could be diluted with methylene chloride and washed with water and brine. The organics could be dried over sodium sulfate and purified by column chromatography.

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