Reaktion #823577

Reaktionsgleichung

product

3-(4-bromophenyl)-5-(trimethylsilyl)isoxazole

CsF

→

title compound

3-(4-bromophenyl)isoxazole

Lösungsmittel

EtOH

MeCN

NH4Cl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with CH2Cl2 (2×7 mL)
2. 2
   ExtraktionThe organic extract
3. 3
   Trocknenwas dried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Einengenthe filtrate concentrated under reduced pressure
6. 6
   SonstigeThe residue was purified by flash chromatography (7% ethyl acetate in hexanes)

Vorschrift

The product from Example 42B (0.103 g) in EtOH (0.7 mL) and MeCN (2.1 mL) was treated with CsF (72 mg, 0.47 mmol), stirred for 5 minutes, diluted with saturated NH4Cl (7 mL), and extracted with CH2Cl2 (2×7 mL). The organic extract was dried (Na2SO4), filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography (7% ethyl acetate in hexanes) to provide the title compound.

Quelle