Reaktion #822565

ord-6719e24673df4614bc96a380de98c19d

Reaktionsgleichung

CCOC(=O)c1ccc(C#C[Se]c2ccc3c(c2)C(C)(C)CC=C3c2ccc(C)cc2)nc1
ethyl 6-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)nicotinate
[Na+].[OH-]
sodium hydroxide
→
Cc1ccc(C2=CCC(C)(C)c3cc([Se]C#Cc4ccc(C(=O)O)cn4)ccc32)cc1
6-(8,8-Dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)nicotinic acid

Edukte

CCOC(=O)c1ccc(C#C[Se]c2ccc3c(c2)C(C)(C)CC=C3c2ccc(C)cc2)nc1
ethyl 6-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)nicotinate
[Na+].[OH-]
sodium hydroxide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigea yellow solid is obtained (0.60 g; yield=71%; m.p.=171° C.)

Vorschrift

In a manner similar to that of Example 7d, by reacting 0.9 g (1.8 mmol) of ethyl 6-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)nicotinate with 0.36 g (9 mmol) of sodium hydroxide, a yellow solid is obtained (0.60 g; yield=71%; m.p.=171° C.).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07592478B2uspto-grants-2009_09