Reaktion #822564

Reaktionsgleichung

methyl 4-[5-(4-methoxyphenyl)-8,8-dimethyl-7,8-dihydro-2-naphthylselanylethynyl]benzoate

sodium hydroxide

hydrochloric acid

→

4-[5-(4-Methoxyphenyl)-8,8-dimethyl-7,8-dihydro-2-naphthylselanylethynyl]benzoic acid

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   SonstigeThe solid obtained
3. 3
   Sonstigeis purified by chromatography (eluent: 3/7 heptane/ethyl acetate)
4. 4
   SonstigeA white solid is obtained (0.28 g; yield=94%; m.p.=167° C.)

Vorschrift

0.31 g (0.62 mmol) of methyl 4-[5-(4-methoxyphenyl)-8,8-dimethyl-7,8-dihydro-2-naphthylselanylethynyl]benzoate is dissolved in 10 ml of tetrahydrofuran and 2 drops of water. 0.075 g (1.86 mmol) of sodium hydroxide is added. The medium is stirred for 2 hours, acidified with 2N hydrochloric acid solution and then extracted with ethyl acetate. The solid obtained is purified by chromatography (eluent: 3/7 heptane/ethyl acetate). A white solid is obtained (0.28 g; yield=94%; m.p.=167° C.).

Quelle