Reaktion #82250

Reaktionsgleichung

6-methoxy-2-tetralone

ethanol

ethyl orthoformate

→

3,4-dihydro-2-ethoxy-6-methoxynaphthalene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture2thus prepared
2. 2
   workup.DISTILLATIONAfter distilling off the solvent under a reduced pressure
3. 3
   Einengenconcentrated
4. 4
   Sonstigeto collect
5. 5
   Sonstigeprecipitated crystals

Vorschrift

33.5 g of 6-methoxy-2-tetralone was dissolved in 27.6 ml of ethanol, followed by subsequently adding 37.8 ml of ethyl orthoformate and one drop of concentrated sulfuric acid. The mixture2thus prepared was stirred at 100° C. for 4 hours. After distilling off the solvent under a reduced pressure, the resulting residue was subjected to silica gel column chromatography using chloroform as an eluant. Fractions of interest were pooled and concentrated to collect precipitated crystals, thereby obtaining 5.82 g of 3,4-dihydro-2-ethoxy-6-methoxynaphthalene.

Quelle