Reaktion #82243

Reaktionsgleichung

5-bromosalicylaldehyde

2-bromo-4-methoxyacetophenone

potassium carbonate

→

5-bromo-2-(4-methoxybenzoyl)benzofuran

Ausbeute 42.6%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe resulting reaction solution
2. 2
   Einengenwas concentrated to dryness
3. 3
   workup.ADDITIONmixed with water
4. 4
   Sonstigeto collect
5. 5
   Sonstigeprecipitated crystals
6. 6
   Filtrationby filtration
7. 7
   WaschenAfter washing with water and subsequent recrystallization from ethanol

Vorschrift

To 150 ml of acetone were suspended 20 g of 5-bromosalicylaldehyde, 22.9 g of 2-bromo-4-methoxyacetophenone and 27.6 g of anhydrous potassium carbonate. After stirring at room temperature for 4 hours, the resulting reaction solution was concentrated to dryness, and then mixed with water to collect precipitated crystals by filtration. After washing with water and subsequent recrystallization from ethanol, 14.02 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran was obtained in the form of colorless prism crystals.

Quelle