Reaktion #822306

Reaktionsgleichung

2-chloro-4-nitrotoluene

tert-butoxybis(dimethylamino)methane

→

[(E)-2-(2-chloro-4-nitrophenyl)vinyl]dimethylamine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 8 hours
2. 2
   SonstigeThe reaction solution is evaporated down
3. 3
   FiltrationThe precipitate is filtered off
4. 4
   Waschenrinsed with petroleum ether
5. 5
   Sonstigedried at ambient temperature under a high vacuum
6. 6
   SonstigeThe product is used in other reactions without further purification

Vorschrift

A reaction mixture of 8.49 g (48 mmol) of 2-chloro-4-nitrotoluene and 15.03 mL (72.8 mmol) of tert-butoxybis(dimethylamino)methane in 200 mL of THF is refluxed for 8 hours. The reaction solution is evaporated down and the residue is combined with petroleum ether. The precipitate is filtered off, rinsed with petroleum ether and dried at ambient temperature under a high vacuum. The product is used in other reactions without further purification. Yield: 11 g, C10H11ClN2O2 (M=226.66); calc.: molecular ion peak (M+H)+: 227/229; found: molecular ion peak (M+H)+: 227/229; Rf value: 0.55 (silica gel, petroleum ether/ethyl acetate (3:1)).

Quelle