Reaktion #822256

Reaktionsgleichung

4-methyl-1-[2-(4-nitrophenoxy)ethyl]piperidine

hydrogen

→

4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylamine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis hydrogenated at ambient temperature
2. 2
   Filtrationfiltered
3. 3
   Sonstigethe filtrate is evaporated down

Vorschrift

A reaction mixture of 680 mg (2.57 mmol) of 4-methyl-1-[2-(4-nitrophenoxy)ethyl]piperidine and 80 mg palladium (10% on charcoal) in 10 mL of methanol is hydrogenated at ambient temperature and 3 bar hydrogen for 4.5 hours. The catalyst is suction filtered and the filtrate is evaporated down. Yield: 540 mg (90% of theory); C14H22N2O (M=234.34); calc.: molecular ion peak (M+H)+: 235; found: molecular ion peak (M+H)+: 235; Rf value: 0.33 (silica gel, dichloromethane/methanol/ammonia (90:10:0.1)).

Quelle