Reaktion #8214

Reaktionsgleichung

nitroethane

6-fluoro-5-methoxy-1H-indole-3-carbaldehyde

ammonium acetate

→

6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole

Ausbeute 92.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Filtrationis filtered

Vorschrift

A mixture of nitroethane(44 ml, 611 mmol), 6-fluoro-5-methoxy-1H-indole-3-carbaldehyde (11.8 g, 61 mmol), and ammonium acetate(1.78 g, 23 mmol) is stirred at 100° C. for 3 hours, allowed to cool, and is filtered to give 14 g of 6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole (92%).

Quelle