Reaktion #82132

Reaktionsgleichung

3,5-diisopropyl-4-hydroxybenzaldehyde

2-nitrophenyl acetic acid

piperidine

→

2,6-diisopropyl-4-(2-nitrostyryl)phenol

Ausbeute 87.0%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   Temperaturunder reflux for 8 hrs
3. 3
   Sonstigewhile removing water producing
4. 4
   Sonstigewith the progress of reaction
5. 5
   workup.DISTILLATIONAfter distilling off the solvent
6. 6
   Sonstigefollowed by purification of the residue by a silica gel column chromatography, recrystallization from hexane

Vorschrift

To a solution of 3,5-diisopropyl-4-hydroxybenzaldehyde (0.95 g, 4.6 mmol) and 2-nitrophenyl acetic acid (1.1 g, 6.2 mmol) in xylene (10 ml) was added piperidine (0.05 ml) and the mixture was heated under reflux for 8 hrs while removing water producing with the progress of reaction. After distilling off the solvent followed by purification of the residue by a silica gel column chromatography, recrystallization from hexane gave 2,6-diisopropyl-4-(2-nitrostyryl)phenol (1.3 g, 87%) as crystals.

Quelle