Reaktion #82130

Reaktionsgleichung

hexane

3,5-di-tert-butyl-4-hydroxybenzaldehyde

2-nitrophenylacetic acid

piperidine

→

2,6-di-tert-butyl-4-(2-nitrostyryl)phenol

Ausbeute 62.9%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   Temperaturunder reflux for 26 hrs
3. 3
   Sonstigewhile removing water producing
4. 4
   Sonstigewith the progress of reaction

Vorschrift

To a solution of 3,5-di-tert-butyl-4-hydroxybenzaldehyde (8.09 g, 34.5 mmol) and 2-nitrophenylacetic acid (9.40 g, 51.9 mmol) in xylene (60 ml) was added piperidine (0.3 ml) and the mixture was heated under reflux for 26 hrs while removing water producing with the progress of reaction. After allowing to stand overnight, hexane was added to afford as crystals 2,6-di-tert-butyl-4-(2-nitrostyryl)phenol (7.67 g, 62.9%).

Quelle