Reaktion #82067

Reaktionsgleichung

3-acetamido-6-fluoro-4-nitrobenzotrifluoride

→

3-amino-6-fluoro-4-nitrobenzotrifluoride

Ausbeute 66.0%

Lösungsmittel

HCl

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   Extraktionit was extracted by ethyl acetate (2×5 mL)
3. 3
   TrocknenThe extract was dried over Mg2SO4
4. 4
   Sonstigeevaporated

Vorschrift

A mixture of 3-acetamido-6-fluoro-4-nitrobenzotrifluoride (593 mg, 2.23 mmol) in concentrated HCl (5 mL) and EtOH (5 mL) was refluxed overnight and it was extracted by ethyl acetate (2×5 mL). The extract was dried over Mg2SO4 and evaporated to give 328 mg (66%) of 3-amino-6-fluoro-4-nitrobenzotrifluoride. 1H NMR (CDCl3): δ 6.105 (S, 2H); 7.110 (d, 1H, J=6.0 Hz); 7.979 (d, 1H, J=10.2 Hz).

Quelle