Reaktion #819843

Reaktionsgleichung

Diisopropylethylamine

tert-butyldimethyl-chlorosilane

(1-benzylpyrrolidin-3-yl)methanol

→

1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl]pyrrolidine

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThereafter, its work-up and purification

Vorschrift

Diisopropylethylamine and tert-butyldimethyl-chlorosilane were added in that order to a chloroform solution of (1-benzylpyrrolidin-3-yl)methanol and stirred at room temperature for 5Hours. Thereafter, its work-up and purification were carried out in the standard method to obtain 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl]pyrrolidine. EP: 306.

Quelle