Reaktion #81896

Reaktionsgleichung

5-cyano-4-methylamino-2-methyl-sulfanyl-pyrimidine

hydrazine hydrate

→

title compound

5-Cyano-2-hydrazino-4-methylamino-pyrimidine

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux
3. 3
   Filtrationthe insoluble product was collected by filtration
4. 4
   Waschenwashed with cold aqueous ethanol (1:1)

Vorschrift

A mixture of 5-cyano-4-methylamino-2-methyl-sulfanyl-pyrimidine (25.86 g) from Example 3 and hydrazine hydrate (52 mL) in ethanol (250 mL) was heated at reflux with stirring for 3 hours. The reaction mixture was cooled to room temperature and the insoluble product was collected by filtration, washed with cold aqueous ethanol (1:1) to give 23 g of the title compound. Crystallization from ethanol afforded an analytically pure sample of 5-cyano-2-hydrazino-4-methylamino-pyrimidine, mp 247°-249° C.

Quelle