Reaktion #81889

ord-a05d8b8e55a9435dae8e8ee9d12176d5

Reaktionsgleichung

CC(=O)c1cc(Nc2cc(C)nc(N)n2)cc(C(C)=O)c1
2-amino-4-(3,5-diacetylphenyl)amino-6-methylpyrimidine
CI
methyl iodide
→
CC(=O)c1cc(Nc2cc(C)[n+](C)c(N)n2)cc(C(C)=O)c1.[I-]
2-amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide

Edukte

CC(=O)c1cc(Nc2cc(C)nc(N)n2)cc(C(C)=O)c1
2-amino-4-(3,5-diacetylphenyl)amino-6-methylpyrimidine
CI
methyl iodide

Reagenzien

Keine

Lösungsmittel

C1CCOC1.CC#N
acetonitrile tetrahydrofuran

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITION2, FIG. 1A: A suspension of Compound No
  2. 2
    Temperaturheated at 40°-45° C. under a reflux condenser for 18 hr
  3. 3
    TemperaturCooling
  4. 4
    Filtrationfiltration

Vorschrift

Compound No. 2, FIG. 1A: A suspension of Compound No. 11 (2-amino-4-(3,5-diacetylphenyl)amino-6-methylpyrimidine) (0.284 g), was suspended in 1:1 acetonitrile-tetrahydrofuran was treated with methyl iodide (2 mL) and heated at 40°-45° C. under a reflux condenser for 18 hr. Cooling and filtration gave 0.35 g of 2-amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide, mp 292° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05620983uspto-grants-1997_04