Reaktion #81831

Reaktionsgleichung

2-chloro-3-cyano-6-(imidazol-1-yl)-4-methylpyridine

sodium hydroxide

sodium bicarbonate

→

title compound

2-Chloro-6-(imidazol-1-yl)-4-methylpyridine-3-carboxamide

Lösungsmittel

sulfuric acid

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crystalline product was removed by filtration
2. 2
   Sonstigedried

Vorschrift

A solution of 2-chloro-3-cyano-6-(imidazol-1-yl)-4-methylpyridine (2.1 g) in concentrated sulfuric acid (5 mL) was heated at 130° C. for 15 minutes. The mixture was cooled to room temperature, diluted with water (10 mL), and adjusted to pH 7 with 20% sodium hydroxide solution followed by solid sodium bicarbonate. The crystalline product was removed by filtration and dried to give 2.35 g of the title compound, suitable for use in the next reaction.

Quelle