Reaktion #81814

Reaktionsgleichung

2-chloro-N-(2-ethylamino-3-pyridinyl)-5-nitro-3-pyridinecarboxamide

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title compound

Ausbeute 58.3%

5,11-Dihydro-11-ethyl-8-nitro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-on

Ausbeute 58.3%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter concentrating in vacuo
2. 2
   Sonstigethe residue was purified on a silical gel column
3. 3
   Wascheneluting with 50% ethyl acetate/hexane

Vorschrift

A solution of 1.80 g of 2-chloro-N-(2-ethylamino-3-pyridinyl)-5-nitro-3-pyridinecarboxamide in 25 ml of xylene was refluxed for four hours. After concentrating in vacuo, the residue was purified on a silical gel column eluting with 50% ethyl acetate/hexane to give 0.93 g of the title compound.

Quelle