Reaktion #81772

Reaktionsgleichung

water

triiodophenol

potassium carbonate

1-bromo-3-octyne

→

desired product

Ausbeute 32.0%

1-(2,4,6-Triiodophenoxy)-3-octyne

Ausbeute 32.0%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   Filtrationthe precipitated solids were collected by filtration
3. 3
   SonstigeThe collected solid was recrystallized from methanol

Vorschrift

A mixture of triiodophenol (1.0 g, 2.1 mmol) and potassium carbonate (0.35 g, 2.54 mmol, 1.2 eq) in 4 ml of dimethylformamide was heated at 70° C. for 1 hr and then cooled to room temperature. 1-bromo-3-octyne was added in a single portion and the mixture was stirred for 1 hr. The reaction mixture was poured into water and the precipitated solids were collected by filtration. The collected solid was recrystallized from methanol to give 0.39 g (32%) of desired product. Mp 45° C.-49° C.

Quelle