Reaktion #81712

Reaktionsgleichung

water

methyl 2-(4'-hydroxymethylphenyl)benzoate

triethylamine

methanesulfonyl chloride

→

title compound

Ausbeute 100.0%

methyl 2-(4'-methanesulfonyloxymethylphenyl)benzoate

Ausbeute 100.0%

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUnder cooling with ice
2. 2
   SonstigeThe reaction liquid
3. 3
   Extraktionfollowed by the extraction with methylene chloride
4. 4
   WaschenAfter the organic phase was washed with water
5. 5
   Sonstigedried
6. 6
   Einengenit was subjected to vacuum concentration

Vorschrift

10.0 g (41 mmol) of methyl 2-(4'-hydroxymethylphenyl)benzoate and 8.4 g (83.0 mmol) of triethylamine were dissolved in methylene chloride (150 ml). Under cooling with ice, a solution of 5.7 g (50 mmol) of methanesulfonyl chloride in methylene chloride (25 ml) was dropwise added thereto, followed by further stirring for one hour. The reaction liquid was poured into water, followed by the extraction with methylene chloride. After the organic phase was washed with water and dried, it was subjected to vacuum concentration. 13.1 g of the title compound was obtained as a wax (yield 100%).

Quelle