Reaktion #816445

ord-b1db7a84356644caa10d461bfd5d2c76

Reaktionsgleichung

CC(C)(C)[O-].[K+]
Potassium tert-butoxide
COC(=O)C(=O)N(C(C)C)S(=O)(=O)Cc1ccccc1
methyl[(benzylsulfonyl)(isopropyl)amino](oxo)acetate
→
CC(C)N1C(=O)C(O)=C(c2ccccc2)S1(=O)=O
4-Hydroxy-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Edukte

CC(C)(C)[O-].[K+]
Potassium tert-butoxide
COC(=O)C(=O)N(C(C)C)S(=O)(=O)Cc1ccccc1
methyl[(benzylsulfonyl)(isopropyl)amino](oxo)acetate

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Potassium tert-butoxide (1.5 g, 13.4 mmol) was added to a solution of crude methyl[(benzylsulfonyl)(isopropyl)amino](oxo)acetate (2.0 g, 21.6 mmol) in DMF (15 mL).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07582629B2uspto-grants-2009_09