Reaktion #816444

Reaktionsgleichung

2-[4-(Difluoromethoxy)benzyl]-4-hydroxy-5-phenylisothiazol-3(2H)-one 1,1-dioxide

DMF

oxalyl chloride

→

title compound

Ausbeute 62.0%

4-Chloro-2-[4-(difluoromethoxy)benzyl]-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Ausbeute 62.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was then heated
2. 2
   Temperaturto reflux for 5 h
3. 3
   Sonstigeevaporated to dryness
4. 4
   workup.ADDITIONWater (20 mL) was added
5. 5
   Extraktionthe reaction mixture was extracted with DCM (20 mL×3)
6. 6
   Waschenwashed with water (50 mL×3) and brine (20 mL)
7. 7
   Trocknendried (MgSO4)
8. 8
   Sonstigeevaporated
9. 9
   SonstigeThe residue was purified by column chromatography (ISOLUTE SI, 20 g/70 mL)
10. 10
    Wascheneluting with DCM:heptane (30:70)

Vorschrift

2-[4-(Difluoromethoxy)benzyl]-4-hydroxy-5-phenylisothiazol-3(2H)-one 1,1-dioxide (0.98 g, ca.60% purity, 1.80 mmol)) was dissolved in DCM (40 mL) and DMF (0.14 mL) was added. Under an atmosphere of nitrogen, oxalyl chloride (0.46 g 3.61 mmol) was dropped in. The mixture was then heated to reflux for 5 h and then evaporated to dryness. Water (20 mL) was added and the reaction mixture was extracted with DCM (20 mL×3). The extracts were combined and washed with water (50 mL×3) and brine (20 mL), dried (MgSO4) and evaporated. The residue was purified by column chromatography (ISOLUTE SI, 20 g/70 mL), eluting with DCM:heptane (30:70), to give the title compound (0.442 g, 62%) as a semi-solid; 1H NMR (400 MHz, CDCl3): δ 7.97 (d, 2H), 7.48-7.58 (m, 5H), 7.11 (d, 2H), 6.51 (t, 1H), 4.86 (s, 2H); 13C NMR (100 MHz, CDCl3): δ 155.8, 151.2, 143.5, 132.5, 130.8, 130.5, 129.4, 128.8, 127.2, 123.2, 119.5, 115.7 (t), 43.1.

Quelle