Reaktion #816439

Reaktionsgleichung

Phenylmethanesulfonyl chloride

2-methoxyethylamine

→

title compound

Ausbeute 99.4%

N-(2-Methoxyethyl)-1-phenylmethanesulfonamide

Ausbeute 99.4%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed
2. 2
   SonstigeThe solvent was removed in vacuo
3. 3
   workup.DISSOLUTIONthe residue was dissolved in DCM
4. 4
   WaschenThe mixture was washed with one portion of 5% aqueous HCl, several portions of water
5. 5
   Sonstigedried through a phase separator
6. 6
   Sonstigeevaporated

Vorschrift

Phenylmethanesulfonyl chloride (3.0 g, 15.7 mmol) was dissolved in dry THF (15 mL) and it was added dropwise to a solution of 2-methoxyethylamine (2.36 g, 31.5 mmol) in dry THF (50 mL) at 0° C. After addition the ice-bath was removed and the reaction was stirred at rt for 2.5 h. The solvent was removed in vacuo and the residue was dissolved in DCM. The mixture was washed with one portion of 5% aqueous HCl, several portions of water, dried through a phase separator and evaporated to give the title compound (3.58 g, 94%); 1H NMR (400 MHz, CDCl3): δ 7.43-7.35 (m, 5H), 4.52 (br s, 1H), 4.26 (s, 2H), 3.40 (t, 2H), 3.32 (s, 3H), 3.14-3.09 (m, 2H); Mass Spectrum: M−H+ 228.

Quelle