Reaktion #816433

Reaktionsgleichung

[[4-(Trifluoromethyl)phenyl]methyl]sulfonyl chloride

ethylamine

→

title compound

Ausbeute 79.0%

N-Ethyl-1-[4-(trifluoromethyl)phenyl]methanesulfonamide

Ausbeute 79.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIt was evaporated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in DCM
3. 3
   Waschenthe resulting mixture was washed with 5% HCl
4. 4
   Sonstigedried
5. 5
   Sonstigeevaporated

Vorschrift

[[4-(Trifluoromethyl)phenyl]methyl]sulfonyl chloride (0.60 g, 2.32 mmol) was added dropwise to a saturated solution of ethylamine in THF (10 mL). The mixture was stirred at room temperature for 1 h. It was evaporated and the residue was dissolved in DCM and the resulting mixture was washed with 5% HCl, dried and evaporated to give the title compound (0.49 g, 79%) as a solid; 1H NMR (500 MHz, CDCl3): δ 7.68 (d, 2H), 7.55 (d, 2H), 4.32 (s, 2H), 4.01 (bs, 1H), 3.08-3.14 (m, 2H), 1.19 (t, 3H); Mass Spectrum: M−H+ 265.

Quelle