Reaktion #816393

Reaktionsgleichung

phytandiol

para-toluene sulfonyl phytandiol

sodium azide

azide

→

azido phytandiol

Ausbeute 81.6%

Lösungsmittel

dimethyl formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby reflux for 5 hr in order
2. 2
   ExtraktionThe reaction mixture was extracted with 50 ml of methylene chloride solution
3. 3
   Waschenwashed with saline
4. 4
   TrocknenFollowing drying over anhydrous magnesium sulfate, filtration and concentration

Vorschrift

The yielded phytandiol derivative (0.48 g) was dissolved in 25 ml of dimethyl formamide and 0.06 g (1.00 mmol) of sodium azide (Sigma-Aldrich) was added, followed by reflux for 5 hr in order to substitute azide for para-toluene sulfonyl group. The reaction mixture was extracted with 50 ml of methylene chloride solution and washed with saline. Following drying over anhydrous magnesium sulfate, filtration and concentration, 0.29 g of azido phytandiol derivative was yielded.

Quelle