Reaktion #81616

Reaktionsgleichung

2,2-dimethylphenethyl acetate

aluminum chloride

→

title compound

4-(4-Chloro-1-oxobutyl)-2,2-dimethylphenethyl acetate

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturPlace under a nitrogen atmosphere, cool to 0°-5° C.
2. 2
   Sonstigeat approximately 0° C
3. 3
   Sonstigequench
4. 4
   workup.ADDITIONby slowly pouring over approximately 2L of crushed ice
5. 5
   workup.STIRRINGAdd methylene chloride (500 mL) and stir for 5 minutes
6. 6
   SonstigeSeparate the organic phase
7. 7
   Extraktionextract the aqueous phase with methylene chloride (300 mL)
8. 8
   WaschenCombine the organic phases and wash with saturated aqueous sodium hydrogen carbonate (3×200 mL), with deionized water (200 mL) and brine (200 mL)
9. 9
   TrocknenDry (MgSO4)
10. 10
    workup.STIRRINGstir for 30 minutes
11. 11
    Filtrationbefore filtering
12. 12
    SonstigeEvaporate the solvent in vacuo
13. 13
    Sonstigepurify by chromatography (ethyl acetate/hexane)

Vorschrift

Charge a flask with aluminum chloride (223 g, 1.68 mol) and methylene chloride (200 mL). Place under a nitrogen atmosphere, cool to 0°-5° C. and add, by dropwise addition, ω-chlorobutyryl chloride (188.6 g, 1.34 mol). After acid chloride addition is complete, add, by dropwise addition, 2,2-dimethylphenethyl acetate (128.0 g, 0.67 mol ), keeping the temperature at approximately 0° C. Continue stirring at 0° C. for 2 hours, quench by slowly pouring over approximately 2L of crushed ice. Add methylene chloride (500 mL) and stir for 5 minutes. Separate the organic phase and extract the aqueous phase with methylene chloride (300 mL). Combine the organic phases and wash with saturated aqueous sodium hydrogen carbonate (3×200 mL), with deionized water (200 mL) and brine (200 mL). Dry (MgSO4) and stir for 30 minutes before filtering. Evaporate the solvent in vacuo and purify by chromatography (ethyl acetate/hexane) to give the title compound as an orange/brown oil.

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