Reaktion #815758

Reaktionsgleichung

product

trans-5-Methoxy-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridine hydrochloride

2-bromo-1-(4-fluorobenzamido)ethane

→

desired product

Ausbeute 32.5%

trans-2-(2-(4-fluorobenzamido)ethyl)-5-methoxy-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]-pyridine hydrochloride

Ausbeute 32.5%

Reaktionsbedingungen

Vorschrift

The product from Example 48 (0.310 g) was treated with 0.34 g 2-bromo-1-(4-fluorobenzamido)ethane as described as described in Example 7 to yield 0.170 g of the desired product as a white solid, mp: 242-4° C. NMR (d6DMSO) δ 1.95 (m, 2H), 2.29 (m, 2H), 2.45-2.75 (m, 2H), 2.82 (m, 2H), 3.05-3.45 (m, 4H), 3.60-3.90 (m, 2H), 3.77 (s, 3H), 6.80 (d, 1H), 6.87 (d, 1H), 7.13 (t, 1H), 7.31 (m, 2H), 8.00 (m, 2H), 8.98 (m, 1H).

Quelle