Reaktion #81571

Reaktionsgleichung

2,4,-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine

nitric acid

sulphuric acid

→

solid

Ausbeute 93.8%

2,4,-Diamino-5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine

Ausbeute 93.8%

Lösungsmittel

ammonia

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting precipitate was collected by filtration
2. 2
   Waschenwashed with water

Vorschrift

2,4,-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine (103.8 g, 0.417 mol) ("Pyrimethamine" obtained from Sigma Chemical Co. Ltd.) was added in portions to a stirred mixture of concentrated nitric acid (210 ml) and concentrated sulphuric acid (210 ml). The mixture was heated at 50° C. for 1 h and then set aside at room temperature for 2.5 days. The reaction mixture was poured onto concentrated ammonia ("0.88" 5 dm3)/ice to effect a neutralisation. The resulting precipitate was collected by filtration and washed with water and sucked to dryness to give nitropyrimethamine as a yellow solid (115 g, 93.8% yield).

Quelle