Reaktion #81546

Reaktionsgleichung

monomethyl terephthalate

4,4-dimethyl-7-amino-1-tetralone

HCl

→

title compound

4-[[(5,6,7,8-Tetrahydro-5,5-dimethyl-8-oxo-2-naphthalenyl)amino]carbonyl]benzoic acid methyl ester

Lösungsmittel

thionylchloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenwas then concentrated in vacuo
2. 2
   ExtraktionIt was extracted with ethyl acetate
3. 3
   Waschenwashed with 1N HCl (4×200 mL)
4. 4
   Waschenwashed with saturated sodium bicarbonate (2×200 mL)
5. 5
   SonstigeThe organic phase was then separated
6. 6
   Trocknendried over magnesium sulfate
7. 7
   Einengenconcentrated in vacuo

Vorschrift

A solution of monomethyl terephthalate (VIIIa) (2.86 g, 15.89 mmoles) in thionylchloride (50 mL) with 2 drops of N,N-dimethylformamide was allowed to stir at room temperature. The mixture became homogeneous within 30 minutes and was then concentrated in vacuo. The residue was then taken up in 30 mL of anhydrous pyridine and treated with 4,4-dimethyl-7-amino-1-tetralone (3.00 g, 15.9 mmoles). After 16 hours at room temperature 1N HCl was added to the mixture. It was extracted with ethyl acetate, washed with 1N HCl (4×200 mL) and washed with saturated sodium bicarbonate (2×200 mL). The organic phase was then separated, dried over magnesium sulfate, and concentrated in vacuo to give 5.07 g (Y: 91% ) of the title compound; 1H-NMR (CDCl3): δ8.27 (dd, J=8.7, 2.5 Hz, 1H), 8.19 (bs, 1H), 8.14 (d, J=8.4 Hz, 2H), 7.95 (d, J=8.4 Hz, 2H), 7.91 (d, J=2.5 Hz, 1H), 7.46 (d, J=8.7 Hz, 1H), 3.94 (s, 3H), 2.70 (t, J=7.0 Hz, 3H), 2.00 (t, J=7.0 Hz, 3H), 1.38 (s, 6H); MS (DCI) m/e: 352 (MH+).

Quelle