Reaktion #81518

Reaktionsgleichung

water

meta-chloroperoxybenzoic acid

ethyl 5-[(3E)-4-(2,6,6-trimethyl-1-cyclohexenyl)but-3-en-1-ynyl)nicotinate

ethyl 3-chloronicotinate

→

Ethyl (±)-6-[(3E)-4-(1,2-Epoxy-2,6,6-trimethylcyclohexanyl)but-3-en-1-ynyl)nicotinate

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with 3×50 mL ether

Vorschrift

0.106 g (0.310 mmol) of 50% meta-chloroperoxybenzoic acid (MCPBA) was added to a solution of 0.1 g (0.310 mmol) of ethyl 5-[(3E)-4-(2,6,6-trimethyl-1-cyclohexenyl)but-3-en-1-ynyl)nicotinate (used as a mixture with 0.6 g (0.310 mmol) of ethyl 3-chloronicotinate), in 10 mL of anhydrous diethyl ether under argon was stirred at ambient temperature for 18 hours. The solution was treated with 10 mL of water and extracted with 3×50 mL ether.

Quelle