Reaktion #814944

ord-657f9c54baf848608026045d8a1307ff

Reaktionsgleichung

O=C(c1ccccc1O)C(F)(F)F
trifluoroacetylphenol
CCCCC[C@H]1CC[C@H](CBr)CC1
trans-4-pentylcyclohexylmethyl bromide
O=C([O-])[O-].[K+].[K+]
K2CO3
→
CCCCC[C@H]1CC[C@H](COc2ccc(C(=O)C(F)(F)F)cc2)CC1
4-(trans-4-pentylcyclohexylmethoxy)-1-trifluoroacetylbenzene

Edukte

O=C(c1ccccc1O)C(F)(F)F
trifluoroacetylphenol
CCCCC[C@H]1CC[C@H](CBr)CC1
trans-4-pentylcyclohexylmethyl bromide
O=C([O-])[O-].[K+].[K+]
K2CO3

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Temperatur
140°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeCustomary work-up and crystallization

Vorschrift

A mixture of 0.1 mol of trifluoroacetylphenol, 0.11 mol of trans-4-pentylcyclohexylmethyl bromide, 0.3 mol of K2CO3 and 250 ml DMF is heated at 140° C. for 10 hours. Customary work-up and crystallization give 4-(trans-4-pentylcyclohexylmethoxy)-1-trifluoroacetylbenzene, mp. 60° C., Δε=13.7.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05045229uspto-grants-1991_09