Reaktion #8147

Reaktionsgleichung

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

n-butylamine

→

2-n-butylamino-4-(3-diethylamino-1-propoxy)nitrobenzene

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Einengenthe reaction mixture is concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue is redissolved in EtOAc (10 mL)
4. 4
   Waschenwashed with saturated sodium bicarbonate solution, water, and brine
5. 5
   TrocknenThe organic phase is then dried over sodium sulfate
6. 6
   Sonstigethe solvent is removed in vacuo

Vorschrift

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with n-butylamine (2.4 eq) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-n-butylamino-4-(3-diethylamino-1-propoxy)nitrobenzene (580 mg) which was used for further transformation without further purification.

Quelle