Reaktion #8146

Reaktionsgleichung

nitro

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

ammonium carbonate

EtOAc

→

2-nitro-5-(3-diethylamino-1-propoxy)aniline

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe combined organic layers are then washed with water and brine
2. 2
   Trocknendried over Na2SO4
3. 3
   SonstigeRemoval of the solvent in vacuo

Vorschrift

The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.

Quelle