Reaktion #81454

ord-55afbf1fd7a040f5abb4ab4db02282e7

Reaktionsgleichung

Cn1c(=O)oc2cc(CN3CCN(c4ccccc4)CC3)cnc21
compound
Cn1c(=O)oc2cc(CN3CCN(c4ccccc4)CC3)cnc21
3-METHYL-6-[(4-PHENYLPIPERAZIN-1-YL)METHYL]OXAZOLO[4,5-b]PYRIDIN-2(3H)-ONE
Cn1c(=O)oc2cc(C(=O)CBr)cnc21
3-methyl-6-(bromoacetyl)oxazolo[4,5-b]pyridin-2(3H)-one
Cn1c(=O)oc2cc(CBr)cnc21
3-methyl-6-(bromomethyl)oxazolo[4,5-b]pyridin-2(3H)-one
→
Cn1c(=O)oc2cc(C(=O)CN3CCN(c4ccccc4)CC3)cnc21
3-METHYL-6-[2-(4-PHENYLPIPERAZIN-1-YL)ACETYL]OXAZOLO[4,5-b]PYRIDIN-2(3H)-ONE

Edukte

Cn1c(=O)oc2cc(CN3CCN(c4ccccc4)CC3)cnc21
compound
Cn1c(=O)oc2cc(CN3CCN(c4ccccc4)CC3)cnc21
3-METHYL-6-[(4-PHENYLPIPERAZIN-1-YL)METHYL]OXAZOLO[4,5-b]PYRIDIN-2(3H)-ONE
Cn1c(=O)oc2cc(C(=O)CBr)cnc21
3-methyl-6-(bromoacetyl)oxazolo[4,5-b]pyridin-2(3H)-one
Cn1c(=O)oc2cc(CBr)cnc21
3-methyl-6-(bromomethyl)oxazolo[4,5-b]pyridin-2(3H)-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe yield obtained

Vorschrift

The method of operation is the same as that used for the synthesis of the compound of Example 16, 3-methyl-6-(bromoacetyl)oxazolo[4,5-b]pyridin-2(3H)-one from Preparation 17 being used instead of 3-methyl-6-(bromomethyl)oxazolo[4,5-b]pyridin-2(3H)-one. The yield obtained is 84%. ##STR70##

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05618819uspto-grants-1997_04