Reaktion #81451

Reaktionsgleichung

sodium borohydride

6-benzoyl-3-methyloxazolo[4,5-b]pyridin-2(3H)-one

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title product

Ausbeute 84.0%

6-(1-PHENYL-1-HYDROXYMETHYL)-3-METHYLOXAZOLO[4,5-b]PYRIDIN-2(3H)-ONE

Ausbeute 84.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenConcentrate the reaction mixture to dryness under reduced pressure
2. 2
   Sonstigeisolate by filtration the resulting product

Vorschrift

Add 42 mg (1.1 mmol) of sodium borohydride to a previously prepared solution of 254 mg (1 mmol) of 6-benzoyl-3-methyloxazolo[4,5-b]pyridin-2(3H)-one in 20 ml of anhydrous methanol. Concentrate the reaction mixture to dryness under reduced pressure after stirring for 5 hours at room temperature, then take up the residue in water and isolate by filtration the resulting product; the title product is obtained in a yield of 84%.

Quelle