Reaktion #8145

ord-f375c00562a24af688c5e95063e27f6d

Reaktionsgleichung

O=[N+]([O-])c1ccc(O)cc1F
3-fluoro-4-nitrophenol
CS(=O)(=O)[O-]
methanesulfonate
CCN(CC)CCCO
3-diethylamino-1-propanol
O=C([O-])[O-].[K+].[K+]
K2CO3
→
CCN(CC)CCCOc1ccc([N+](=O)[O-])c(F)c1
2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

Edukte

O=[N+]([O-])c1ccc(O)cc1F
3-fluoro-4-nitrophenol
CS(=O)(=O)[O-]
methanesulfonate
CCN(CC)CCCO
3-diethylamino-1-propanol
O=C([O-])[O-].[K+].[K+]
K2CO3

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturheated

Vorschrift

A solution of 3-fluoro-4-nitrophenol (2 mmol) and methanesulfonate of 3-diethylamino-1-propanol (2.5 mmol) in DMF (4 mL) is added with K2CO3 (4 mmol) and heated following the general procedure III (Step A). The product, 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene is obtained (470 mg) after purification using silica gel column chromatography.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087632B2uspto-grants-2006_08