Reaktion #8142

Reaktionsgleichung

( 1 )

2-cyclopropylmethyl-4-[3-(4-tert-butoxycarbonyl-1-piperazinyl)propyl]-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-methanesulfonyloxypropyl)-2H-pyridazin-3-one

→

title compound

Ausbeute 67.8%

4-(3-aminopropyl)-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

Ausbeute 67.8%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas reacted
2. 2
   Sonstigeto yield a crude product
3. 3
   SonstigeWithout purification
4. 4
   Sonstigethe crude product was reacted further in accordance with the procedure of Example 24 (2)

Vorschrift

Following the procedure of Example 24 (1), 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-methanesulfonyloxypropyl)-2H-pyridazin-3-one was reacted to yield a crude product. Without purification, the crude product was reacted further in accordance with the procedure of Example 24 (2) to yield the title compound as a yellow oil (yield: 67.8%).

Quelle