Reaktion #81407

Reaktionsgleichung

azide

sodium azide

N-tert-butyl 2-(3-bromo-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-1-yl) ethanoic acid amide

dimethylformamide

→

foam

Ausbeute 80.1%

N-tert-butyl-2-(3-azido-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-1-yl)ethanoic acid amide

Ausbeute 80.1%

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 125 ml round-bottomed flask equipped with a nitrogen inlet
2. 2
   workup.DISSOLUTIONAfter dissolution
3. 3
   Temperaturthe solution heated at 80°-85° C. for 4 hours 20 minutes (at this point, tlc and NMR of an aliquot
4. 4
   TemperaturThe reaction was cooled
5. 5
   Extraktionextracted twice into ethyl acetate
6. 6
   WaschenThe organic layer was washed with water and brine
7. 7
   Trocknendried over sodium sulfate
8. 8
   Sonstigeevaporated
9. 9
   SonstigeThe residue was chromatographed on silica gel using 3:1 hexane/ethyl acetate

Vorschrift

To a 125 ml round-bottomed flask equipped with a nitrogen inlet were added 8.2 grams (18.5 mmol) N-tert-butyl 2-(3-bromo-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-1-yl) ethanoic acid amide and 40 ml dimethylformamide. After dissolution, a solution of 1.44 grams (22.2 mmol) sodium azide in 2 mL water (with two additional 0.75 ml portions of water) was added, and the solution heated at 80°-85° C. for 4 hours 20 minutes (at this point, tlc and NMR of an aliquot indicated a 75/15/10 ratio of desired azide/isomeric azide/starting material). The reaction was cooled, poured into water, and extracted twice into ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and evaporated. The residue was chromatographed on silica gel using 3:1 hexane/ethyl acetate to give 5.80 grams (77%) of a foam which solidified.

Quelle