Reaktion #81387

ord-ae91c6b8e97a4af6ad5156e881e403e0

Reaktionsgleichung

CCOP(=O)(OCC)C(c1ccc2cc(O)ccc2c1)P(=S)(OCC)OCC
tetraethyl 6-hydroxy-2-naphthylthiomethanediphosphonate
C[Si](C)(C)Br
trimethylsilyl bromide
→
O=P(O)(O)C(c1ccc2cc(O)ccc2c1)P(O)(O)=S
title compound
Ausbeute 84.0%
O=P(O)(O)C(c1ccc2cc(O)ccc2c1)P(O)(O)=S
6-Hydroxy-2-naphthylthiomethanediphosphonic Acid
Ausbeute 84.0%

Edukte

CCOP(=O)(OCC)C(c1ccc2cc(O)ccc2c1)P(=S)(OCC)OCC
tetraethyl 6-hydroxy-2-naphthylthiomethanediphosphonate
C[Si](C)(C)Br
trimethylsilyl bromide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the same method as in Example 2, 7.15 g (15 mmol) of the tetraethyl 6-hydroxy-2-naphthylthiomethanediphosphonate obtained in Example 5 was treated with trimethylsilyl bromide, and then hydrolyzed to obtain 4.21 g of the title compound as white crystals.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05618804uspto-grants-1997_04