Reaktion #81386

ord-25ec6e787a3f4a23aa117cf2e6b6a982

Reaktionsgleichung

CCOP(=O)(OCC)C(c1ccc2cc(OC)ccc2c1)P(=S)(OCC)OCC
tetraethyl 6-methoxy-2-naphthylthiomethanediphosphonate
C[Si](C)(C)Br
trimethylsilyl bromide
→
COc1ccc2cc(C(P(=O)(O)O)P(O)(O)=S)ccc2c1
title compound
Ausbeute 80.6%
COc1ccc2cc(C(P(=O)(O)O)P(O)(O)=S)ccc2c1
6-Methoxy-2-naphthylthiomethanediphosphonic Acid
Ausbeute 80.6%

Edukte

CCOP(=O)(OCC)C(c1ccc2cc(OC)ccc2c1)P(=S)(OCC)OCC
tetraethyl 6-methoxy-2-naphthylthiomethanediphosphonate
C[Si](C)(C)Br
trimethylsilyl bromide

Reagenzien

Keine

Lösungsmittel

ClCCl
methylene chloride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the same method described as in Example 2, 7.15 g (15 mmol) of tetraethyl 6-methoxy-2-naphthylthiomethanediphosphonate obtained in Example 3 in dry methylene chloride was treated with trimethylsilyl bromide, and then hydrolyzed to obtain 4.21 g of the title compound as white crystals. The yield was 77%.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05618804uspto-grants-1997_04