Reaktion #813406

Reaktionsgleichung

3-phenylpropanamine

3-(1H-imidazol-4-yl)propanoic acid

→

N-(3-Phenylpropyl)-3-(1H-imidazol-4-yl)propanamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe acid being here added
2. 2
   ExtraktionThe title compound is extracted from water with diethyl ether
3. 3
   Sonstigepurified by chromatography
4. 4
   Sonstigerecrystallized in the hydrogenmaleate form from ethanol/diethyl ether

Vorschrift

The preparation is carried out as in Example 1 with 3-phenylpropanamine and 3-(1H-imidazol-4-yl)propanoic acid, the acid being here added after the reaction of the amine component with N,N'-carbonyldiimidazole. The title compound is extracted from water with diethyl ether, purified by chromatography and recrystallized in the hydrogenmaleate form from ethanol/diethyl ether.

Quelle