Reaktion #813298
ord-da408afdec104d10ab586c6ceb20fbe1
Reaktionsgleichung
4-bromo-3-chloro-3,4,4-trifluorobutanal
1-chloro-1,2-dibromotrifluoroethane
ethyl vinyl ether
sodium hydrosulfite sodium bicarbonate
sodium chlorite hydrogen peroxide
→
4-bromo-3-chloro-3,4,4-trifluorobutanoic acid
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
A one pot reaction of 1-chloro-1,2-dibromotrifluoroethane (VI) with ethyl vinyl ether in the presence of sodium hydrosulfite/sodium bicarbonate followed by oxidation of the intermediate, 4-bromo-3-chloro-3,4,4-trifluorobutanal (VII), without isolation, with sodium chlorite/hydrogen peroxide to give 4-bromo-3-chloro-3,4,4-trifluorobutanoic acid (VIII) in overall unexpected yields;