Reaktion #81282

Reaktionsgleichung

methyl 4-(1-hydroxy-1-methylethyl)-2-methoxymethylimidazole-5-carboxylate

potassium t-butoxide

4-[2-(t-butoxycarbonyl)phenyl]benzyl bromide

→

title compound

Ausbeute 93.9%

Methyl 1-{4-[2-(t-butoxycarbonyl)phenyl]phenyl}methyl-4-(1-hydroxy-1-methylethyl)-2-methoxymethylimidazole-5-carboxylate

Ausbeute 93.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurifying the product by column chromatography through silica gel using a 1:2
2. 2
   workup.ADDITIONby volume mixture of hexane and ethyl acetate as the eluent

Vorschrift

Following a procedure similar to that described in Example 82(a), but using 230 mg of methyl 4-(1-hydroxy-1-methylethyl)-2-methoxymethylimidazole-5-carboxylate [prepared as described in Preparation 42(v)], 119 mg of potassium t-butoxide and 420 mg of 4-[2-(t-butoxycarbonyl)phenyl]benzyl bromide and then purifying the product by column chromatography through silica gel using a 1:2 by volume mixture of hexane and ethyl acetate as the eluent, 468 mg of the title compound were obtained as a syrup.

Quelle