Reaktion #81240

Reaktionsgleichung

4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide

potassium t-butoxide

ethyl 2-ethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

→

title compound

Ausbeute 64.7%

Ethyl 2-ethyl-4-(1-hydroxy-1-methylethyl)-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Ausbeute 64.7%

Lösungsmittel

N,N-dimethylacetamide

N,N-dimethylacetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGafter which the reaction mixture was stirred at 50° C. for 4 hours

Vorschrift

0.52 g of potassium t-butoxide was added to a solution of 1.00 g of ethyl 2-ethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate (prepared as described in Preparation 37) in 26 ml of N,N-dimethylacetamide, and the resulting mixture was stirred at room temperature for 10 minutes. A solution of 2.71 g of 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide in 35 ml of N,N-dimethylacetamide was then added dropwise to the resulting solution, after which the reaction mixture was stirred at 50° C. for 4 hours. At the end of this time, the reaction mixture was worked up in a similar manner to that described in Example 18(a), to give 2.01 g of the title compound as crystals, melting at 150°-152° C.

Quelle